Motif ID: FOX{C1,C2}.p2

Z-value: 0.753


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXC2chr16_+_851583570.234.0e-01Click!
FOXC1chr6_+_1555679-0.165.4e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_120375053 0.854 NM_006952
UPK1B
uroplakin 1B
chr17_-_45626364 0.817


chr8_-_125785611 0.815 MTSS1
metastasis suppressor 1
chr10_-_27097782 0.758 ABI1
abl-interactor 1
chr20_+_56904042 0.735 GNAS
GNAS complex locus
chr9_-_74735669 0.730 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr8_+_20099179 0.708 ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr8_+_20099169 0.663 ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr10_-_98315090 0.650 TM9SF3
transmembrane 9 superfamily member 3
chr14_+_64041257 0.630 ZBTB1
zinc finger and BTB domain containing 1
chr2_-_158008763 0.619 NM_004288
CYTIP
cytohesin 1 interacting protein
chr20_+_9146036 0.573 NM_182797
PLCB4
phospholipase C, beta 4
chr15_+_84486245 0.567 NM_152336
AGBL1
ATP/GTP binding protein-like 1
chr1_-_56750235 0.520 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_68688219 0.505 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chr15_-_56093477 0.494 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr14_+_99601498 0.470 NM_016337
EVL
Enah/Vasp-like
chr3_-_52688768 0.465 NM_018165
NM_181042
PBRM1

polybromo 1

chr14_+_99601517 0.449 EVL
Enah/Vasp-like
chr11_+_113672407 0.447 NNMT
nicotinamide N-methyltransferase
chr5_-_58918031 0.434 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_+_147695314 0.428 NM_001040433
SPINK9
serine peptidase inhibitor, Kazal type 9
chr11_-_9182356 0.427 DENND5A
DENN/MADD domain containing 5A
chr7_-_87694218 0.421 NM_198901
SRI
sorcin
chr6_-_138862271 0.416 NM_001144060
NHSL1
NHS-like 1
chr9_+_5646582 0.412 NM_020829
KIAA1432
KIAA1432
chr2_+_73973600 0.404 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr8_-_13018123 0.401 NM_001164271
DLC1
deleted in liver cancer 1
chr5_+_147529488 0.400 NM_001001325
SPINK14
serine peptidase inhibitor, Kazal type 14 (putative)
chr17_-_45620313 0.376


chr13_-_98757634 0.371 NM_004951
GPR183
G protein-coupled receptor 183
chr4_+_74500748 0.370 ALB
albumin
chr20_+_42644633 0.366 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr2_+_73973640 0.361 ACTG2
actin, gamma 2, smooth muscle, enteric
chr4_+_71298187 0.349 NM_021225
PROL1
proline rich, lacrimal 1
chr7_-_7724762 0.346 NM_002947
RPA3
replication protein A3, 14kDa
chr11_+_113672378 0.331 NNMT
nicotinamide N-methyltransferase
chr17_-_45626967 0.321


chr5_-_32439067 0.317 ZFR
zinc finger RNA binding protein
chr3_-_192531018 0.290 NM_198152
UTS2D
urotensin 2 domain containing
chr20_+_56903595 0.282 GNAS
GNAS complex locus
chr9_+_123088217 0.281 GSN
gelsolin
chr3_+_134978615 0.280 TF
transferrin
chr7_+_141265085 0.276 NM_001001656
OR9A4
olfactory receptor, family 9, subfamily A, member 4
chr22_-_39189369 0.274 MKL1
megakaryoblastic leukemia (translocation) 1
chr10_+_42953886 0.273 NM_018590
CSGALNACT2
chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr3_+_185516630 0.272 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr12_-_25597444 0.259 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr6_+_7053183 0.256 RREB1
ras responsive element binding protein 1
chr6_-_138862273 0.253


chr6_+_142510108 0.246 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr18_+_41558141 0.243 SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr14_-_23623657 0.242 NM_006177
NRL
neural retina leucine zipper
chr3_+_186529376 0.238 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr16_+_24475129 0.235 RBBP6
retinoblastoma binding protein 6
chr11_+_65027721 0.233


chr12_+_15017222 0.231 NM_006205
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr4_-_68678181 0.229 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr14_-_93988838 0.227 NM_001080451
SERPINA11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
chr4_+_71054492 0.223 NM_214711
C4orf40
chromosome 4 open reading frame 40
chr9_+_124321239 0.219 NM_001004452
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr17_+_19917420 0.217 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr6_+_142510075 0.217 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr5_+_38881719 0.216 NM_003999
OSMR
oncostatin M receptor
chr6_+_142510094 0.214 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr3_+_115099007 0.213 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr6_+_142510034 0.211 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr2_+_189547323 0.211 NM_000090
COL3A1
collagen, type III, alpha 1
chr1_+_198263352 0.208 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr7_+_104468614 0.207 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr11_+_48194937 0.207 NM_001005470
OR4B1
olfactory receptor, family 4, subfamily B, member 1
chr2_+_189547358 0.207 COL3A1
collagen, type III, alpha 1
chr4_+_169250281 0.206 NM_007193
ANXA10
annexin A10
chr9_-_25668855 0.201 NM_001004125
TUSC1
tumor suppressor candidate 1
chr2_-_207291364 0.199 NM_001093730
DYTN
dystrotelin
chr14_+_64041170 0.198 ZBTB1
zinc finger and BTB domain containing 1
chr14_+_100365162 0.197 MEG3
maternally expressed 3 (non-protein coding)
chr14_+_22059212 0.194


chr2_+_87536174 0.194 NCRNA00152
non-protein coding RNA 152
chr2_+_234286376 0.193 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr10_+_90414125 0.193 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr1_-_155788775 0.191 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr13_+_96672705 0.190 MBNL2
muscleblind-like 2 (Drosophila)
chr1_-_160648429 0.185 NM_053282
SH2D1B
SH2 domain containing 1B
chr9_+_5619326 0.185 NM_001135920
KIAA1432
KIAA1432
chr16_+_54158084 0.183 NM_032330
CAPNS2
calpain, small subunit 2
chr9_-_106329310 0.180 NM_001001919
OR13C4
olfactory receptor, family 13, subfamily C, member 4
chr11_+_111294868 0.178 C11orf52
chromosome 11 open reading frame 52
chr19_+_8415875 0.177 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr2_+_87536106 0.176 NCRNA00152
non-protein coding RNA 152
chr12_-_120196363 0.176 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr12_+_26003218 0.175 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr12_+_70519753 0.174 NM_001146213
NM_001146214
NM_022771
TBC1D15


TBC1 domain family, member 15


chr10_-_112668892 0.173 NM_001195304
NM_001195305
NM_001195307
BBIP1


BBSome interacting protein 1


chr4_+_74491272 0.173 ALB
albumin
chr6_+_64414389 0.173 NM_015153
PHF3
PHD finger protein 3
chr16_-_21130368 0.171 NM_003460
ZP2
zona pellucida glycoprotein 2 (sperm receptor)
chr19_+_8415869 0.171 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr8_+_20098983 0.170 NM_001693
ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr5_+_140154627 0.170 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr9_+_111442888 0.169 NM_001037293
PALM2
paralemmin 2
chr11_+_117680504 0.168 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr19_+_8415859 0.166 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr12_+_25096755 0.166 LRMP
lymphoid-restricted membrane protein
chr5_+_150000394 0.166 NM_001109974
NM_007286
SYNPO

synaptopodin

chr1_+_26358097 0.165 NM_024869
GRRP1
glycine/arginine rich protein 1
chr19_+_53520632 0.164 EMP3
epithelial membrane protein 3
chr8_+_104900591 0.161 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr18_-_55177430 0.161 NM_005570
LMAN1
lectin, mannose-binding, 1
chr15_+_55671393 0.161 NM_001018090
NM_001018091
NM_001018100
NM_152451
GCOM1



GRINL1A complex locus



chr16_+_68238460 0.158 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr13_-_19244398 0.157 PSPC1
paraspeckle component 1
chr11_+_110890719 0.157 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr2_+_189547377 0.157 COL3A1
collagen, type III, alpha 1
chr12_+_25096472 0.156 NM_006152
LRMP
lymphoid-restricted membrane protein
chr12_-_54522881 0.155 NM_002429
MMP19
matrix metallopeptidase 19
chr1_+_94656517 0.155 NM_001122674
NM_002858
ABCD3

ATP-binding cassette, sub-family D (ALD), member 3

chr3_-_158700036 0.154 NM_024621
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr9_+_124526089 0.154 NM_001005235
OR1L4
olfactory receptor, family 1, subfamily L, member 4
chr11_-_61823078 0.153 NM_206998
SCGB1D4
secretoglobin, family 1D, member 4
chr11_-_8789457 0.153 NM_139157
ST5
suppression of tumorigenicity 5
chr19_+_8415802 0.151 NM_005968
NM_031203
HNRNPM

heterogeneous nuclear ribonucleoprotein M

chr9_-_34719463 0.150 NM_001141917
C9orf144B
transmembrane protein C9orf144B
chr22_-_35970230 0.149 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr21_-_37366684 0.148 NM_153681
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr20_-_1321571 0.145 FKBP1A
FK506 binding protein 1A, 12kDa
chr14_+_23527866 0.142 NM_198083
DHRS4
DHRS4L2
dehydrogenase/reductase (SDR family) member 4
dehydrogenase/reductase (SDR family) member 4 like 2
chr18_-_63333487 0.142 DSEL
dermatan sulfate epimerase-like
chr3_+_195336625 0.139 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr11_-_13474101 0.137 NM_000315
PTH
parathyroid hormone
chr19_-_47723183 0.137 CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr11_-_123182266 0.133 NM_001005325
OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr15_-_41381744 0.132 NM_052955
TGM7
transglutaminase 7
chr2_+_137464931 0.132 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr3_-_116272911 0.131 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr22_-_35970133 0.131 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr6_+_88026338 0.131 ZNF292
zinc finger protein 292
chr12_-_47735373 0.130 NM_003482
MLL2
myeloid/lymphoid or mixed-lineage leukemia 2
chr2_-_215998181 0.130 FN1
fibronectin 1
chr11_+_55351270 0.129 NM_001004739
OR5L2
olfactory receptor, family 5, subfamily L, member 2
chr7_+_99263571 0.127 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr9_-_130683997 0.127 NM_001122671
NM_001122672
NM_004059
CCBL1


cysteine conjugate-beta lyase, cytoplasmic


chr5_-_156525756 0.127 NM_130899
FAM71B
family with sequence similarity 71, member B
chr2_+_48649662 0.126 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr6_+_72982865 0.126 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr12_+_45896511 0.126 FAM113B
family with sequence similarity 113, member B
chr2_-_233349469 0.125 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr5_+_96064248 0.125 NM_173060
CAST
calpastatin
chr11_-_2113297 0.124 IGF2
insulin-like growth factor 2 (somatomedin A)
chr14_+_73884947 0.124 VRTN
vertebrae development homolog (pig)
chr8_+_103633023 0.124 NM_024410
ODF1
outer dense fiber of sperm tails 1
chr3_-_120761092 0.123 NM_005191
CD80
CD80 molecule
chr19_+_15713200 0.123 NM_013938
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr11_+_111294810 0.122 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr16_+_85158357 0.121 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr19_-_9087438 0.121 NM_001005192
OR7G1
olfactory receptor, family 7, subfamily G, member 1
chr22_+_38652555 0.120 GRAP2
GRB2-related adaptor protein 2
chr9_-_112139908 0.120 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr20_-_14266200 0.120 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr2_-_88066423 0.119 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr16_-_52295214 0.119 NM_001127897
NM_015272
RPGRIP1L

RPGRIP1-like

chr12_+_115455579 0.119 NCRNA00173
non-protein coding RNA 173
chr5_-_88004891 0.118 LOC645323
hypothetical LOC645323
chr14_+_23849196 0.117 NM_001164692
NM_019839
LTB4R2

leukotriene B4 receptor 2

chr2_+_69055208 0.117 NM_019617
GKN1
gastrokine 1
chr2_-_74424041 0.116 NM_133478
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr5_+_156752739 0.115 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr18_-_53438854 0.115


chr14_+_22059174 0.113


chr16_+_68157611 0.113 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr10_-_91393610 0.113 NM_138316
NM_148978
PANK1

pantothenate kinase 1

chr14_+_50096603 0.113 ATL1
atlastin GTPase 1
chr9_+_130684189 0.113 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chr5_+_43645018 0.109 NNT
nicotinamide nucleotide transhydrogenase
chr12_+_58276114 0.109 SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chrX_+_15435351 0.107 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr1_-_154665807 0.107 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr2_+_132196533 0.107 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr9_+_133295297 0.106 NM_013318
PRRC2B
proline-rich coiled-coil 2B
chr7_+_94123672 0.106 PEG10
paternally expressed 10
chr12_-_55316350 0.105 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr1_-_156923111 0.105 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr10_+_111755715 0.105 NM_019903
ADD3
adducin 3 (gamma)
chr2_+_158666627 0.104 NM_173355
UPP2
uridine phosphorylase 2
chr6_+_83834080 0.104 NM_015018
DOPEY1
dopey family member 1
chr5_+_112071087 0.103 NM_001127511
APC
adenomatous polyposis coli
chr2_-_224612177 0.103 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr5_+_159368690 0.102 TTC1
tetratricopeptide repeat domain 1
chr11_+_120478584 0.102 NM_005422
TECTA
tectorin alpha
chr3_+_195336631 0.102 HES1
hairy and enhancer of split 1, (Drosophila)
chr4_-_90197140 0.102 NM_014883
FAM13A
family with sequence similarity 13, member A
chr9_-_15240113 0.102 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr20_-_1321744 0.101 NM_000801
NM_054014
FKBP1A

FK506 binding protein 1A, 12kDa

chr17_-_64649608 0.101 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr1_+_62675296 0.101 USP1
ubiquitin specific peptidase 1
chr12_+_54231249 0.100 NM_001005494
OR6C4
olfactory receptor, family 6, subfamily C, member 4
chr17_+_70964258 0.100 NM_014738
KIAA0195
KIAA0195
chr15_+_97010219 0.099 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr1_+_151081953 0.099 NM_001128600
LCE6A
late cornified envelope 6A
chr14_+_73884918 0.098 NM_018228
VRTN
vertebrae development homolog (pig)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.82 1.28e-03 GO:0007608 sensory perception of smell
2.62 3.77e-03 GO:0007606 sensory perception of chemical stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 7.17e-04 GO:0071944 cell periphery
1.42 8.77e-04 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.86 3.95e-04 GO:0004984 olfactory receptor activity
2.08 2.33e-02 GO:0005509 calcium ion binding
1.72 3.28e-02 GO:0004888 transmembrane receptor activity
1.91 4.09e-02 GO:0004930 G-protein coupled receptor activity
6.13 4.29e-02 GO:0019825 oxygen binding
3.61 4.36e-02 GO:0046906 tetrapyrrole binding
1.59 4.82e-02 GO:0004872 receptor activity